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PREMPRO™/PREMARIN™  |  Prempro FAQs

Welcome to the Brown & Crouppen Prempro / Premarin page. Brown & Crouppen is one of mid-America’s largest personal injury litigators. We have been building our reputation for legal success for almost a quarter of a century. We have thrived because of our shared commitment to deliver the best possible service to clients throughout Missouri and the United States. Today, our team has grown to over 70 legal professionals and five offices throughout Missouri and Illinois. In recent years, the firm has seen a surge in the number of clients suffering injury from unsafe drugs. We have successfully tackled the prescription drug giants who make Rezulin™, Fen-Phen™, Lotronex™, OxyContin™, Zyprexa™, PPA™, Ephedra, and Prempro™.

Our firm’s skills, credentials and resources have helped thousands of clients win millions of dollars from the manufacturers and suppliers of unsafe drugs and products.

Nationwide, there are an estimated 6 million women taking the prescription drug Prempro. Prempro is a leading Hormone Replacement Therapy (HRT) drug that combines estrogen and progestin into one pill. It is prescribed to treat women experiencing menopausal symptoms that include mood swings, hot flashes, night sweats, vaginal dryness and osteoporosis.

When first introduced, it was believed that HRT could reduce the risk of osteoporosis and heart complications in women. However, in July 2002, the National Institute of Health (NIH) halted a major clinical study of 16,000 women due to alarming preliminary findings. The data suggested that after only one year on Prempro, an otherwise healthy woman faced increased risk of
  • Heart attack (by 29%)
  • Breast cancer (by 24%)
  • Blood clots (by 200%)
  • Stroke (by 41%).
  • The National Cancer Institute also reported in another study that ovarian cancer risk in postmenopausal women increased to 220% if they took estrogen for more than 20 years.

For almost 40 years, women have been encouraged to take drugs like Prempro to relieve menopausal symptoms – yet these drugs were recommended on unreliable medical evidence. Wyeth pharmaceutical company, who is the manufacturer of Prempro, has no plans to recall the drug. Prempro bring almost $1.4 billion in revenue to Wyeth’s coffer each year.

We believe that drug companies who place profit above people must be held accountable for their negligence and the damage they cause to innocent victim’s lives.

In response to the Prempro controversy, Wyeth has issued new guidelines that caution against long-term use and has reduced the drug’s recommended dosage by half. Unfortunately, it may be too little too late for the many women who have suffered adverse effects. Unsafe prescription drugs have been marketed without comprehensive testing or have inadequate warning labels. Even more alarming is the fact that many of the tests required by the Food and Drug Administration (who regulates the prescription drug market) may be funded by the drug manufacturer.

If you, or someone you know, has been treated using estrogen or a combination of estrogen/progestin hormone replacement therapy, we suggest contacting your doctor immediately to discuss whether HRT is the best course of treatment.

If you have suffered harmful effects from Prempro such as breast cancer, stroke or heart attack, you may be entitled to file a legal claim against the drugs maker for negligence in product labeling and marketing. Brown & Crouppen has represented many victims of defective drugs, and as our client, you will be backed by a team of legal professionals, medical experts and investigators who are committed to ensuring that your rights are protected.

Brown & Crouppen can help you make informed decisions about your legal rights, so please call Brown & Crouppen at 1-800-536-HELP for your free legal consultation or save time with our online Contact Form.

For additional HRT / Prempro information, click here.
Prempro Lawyers and Alternatives


What are the different types of hormone therapies?

How many postmenopausal women take estrogen alone or estrogen plus progestin therapy?

What is the important information about Premarin and Prempro and all estrogens and estrogens plus progestins drug products?

What are the dangers associated with Prempro?

Are Premarin and Prempro safer in lower doses?

Is it dangerous to abruptly stop HRT? Should Prempro be stopped gradually? Will I bleed if I stop taking Prempro?

Are there alternatives to HRT?

Are the estrogens and progestins in birth control pills (oral contraceptives) the same as those in Prempro and Premarin? Do they have the same risks?

What are the different types of hormone therapies?
There are a wide range of different hormone therapies – patches and pills, natural and synthetic, combinations of estrogen and progesterones, and individual estrogen and progesterones. Prempro, Premarin, Provera, Estrogen therapy... and each has its own risks and potential benefits. Informing yourself of the possible dangers is important, and only you and your doctor can determine the most effective and safe method of treatment.

Therapy
Terminology
Newer Terminology
Using estrogen with or without progestin Hormone replacement therapy (HRT) Hormone therapy (HT)
Using estrogen alone Estrogen replacement therapy (ERT) Estrogen therapy (ET)
Using estrogen with a progestin Hormone replacement therapy (HRT) Estrogen-progestin therapy (EPT)


How many postmenopausal women take estrogen alone or estrogen plus progestin therapy?

Wyeth estimates that approximately 5 million U.S. women are taking Premarin and 1.5 million are taking Prempro. Approximately 10 million postmenopausal women are taking some form of estrogen, either alone or in combination with a progestin.

What is the important information about Premarin and Prempro and all estrogens and estrogens plus progestins drug products?

Premarin and Prempro, as well as other estrogen and estrogen plus progestin drug products have associated risks that may outweigh the benefits for women. A major HRT study released by the Womens Health Initiative shows (read study):

  • Postmenopausal women should not take estrogen and progestin to protect the heart.
  • Estrogens and progestins may increase the risk of heart attack, stroke, blood clots and breast cancer.
  • Although other doses of Prempro and other estrogens and progestins were not studied, postmenopausal women who take estrogens and progestins should also be warned about potential risks, which must be presumed to be the same.
  • When these drugs are being prescribed only to prevent osteoporosis, other treatments should be considered before prescribing estrogen or estrogen with progestin.
  • Estrogens and estrogens with progestins should be used at the lowest dose for the shortest duration.

What are the dangers associated with Prempro?
Study results show that for every 10,000 healthy, postmenopausal women taking PremPro for a year, there would be eight additional cases of breast cancer, seven heart attacks, eight strokes and eight blood clots in the lungs. At first glance, those numbers don’t seem significant. However, in 2002, more than 6 million women were taking PremPro. Statistically, that translates into:

  • 480,000 additional breast cancer cases.

  • 420,000 more heart attacks.

  • 480,000 more strokes.

  • 480,000 more blood clot cases.

Study results on the effects of Prempro also show:

  • 26 percent increase in breast cancer.

  • 41 percent increase in strokes.

  • 29 percent increase in heart attacks.

  • 100 percent increase of blood clots in legs and lungs.

Raising more red flags is the reported increase in the incidence of ovarian cancer in WHI study participants. Women who took estrogen HRTs for long periods of time had a higher risk of developing the rare form of cancer, and researchers noted a 7 percent increase in risk associated with every extra year of estrogen HRT use. Researchers called the trend “worrisome.”

Are Premarin and Prempro safer in lower doses?
The dose of Prempro used in the WHI study was 0.625 mg, which is the same as 0.625 mg Premarin (conjugated estrogens) plus 2.5 mg medroxyprogesterone acetate (progestin). It is not known whether Premarin and Prempro are safer in lower doses. Generally, medicines should be used at the lowest effective dose. The FDA cannot make further recommendations until studies are performed using lower doses.

Is it dangerous to abruptly stop HRT? Should Prempro be stopped gradually? Will I bleed if I stop taking Prempro?

It is not dangerous to just stop your HRT. You may get some minimal bleeding if you stop HRT, but that is not dangerous. Your menopausal symptoms such as hot flashes may return if you stop HRT.

Are there alternatives to HRT?
Absolutely, but it depends on what symptoms you are treating or what diseases you are trying to prevent. There are multiple herbal supplements that have been found to help against hot flashes, such as black cohash. There are excellent medications for the prevention and treatment of osteoporosis. There are estrogen medications that can be applied just to the vagina that help treat vaginal dryness. Exercise and diet can also go along way to prevent the side effects of menopause. You should talk to your doctor about your symptoms and the options available to you.
Learn more about Prempro alternatives.

Are the estrogens and progestins in birth control pills (oral contraceptives) the same as those in Prempro and Premarin? Do they have the same risks?
Oral contraceptives also contain estrogens and progestins, but different types and doses. All estrogens have similar side effects. However, the risks of particular side effects may differ since oral contraceptives are used in younger women with different health status compared to postmenopausal women.

As with all estrogens, the use of oral contraceptives is also associated with increased risks of several serious conditions including heart attack, blood clots, stroke, liver tumors, and gallbladder disease. These risks are higher in women with underlying risk factors such as high blood pressure, high cholesterol, and diabetes, and in those who smoke cigarettes.

My name is Ron Brown, along with my partner Terry Crouppen we founded Brown and Crouppen almost 20 years ago. Today, we are proud to say that we are one of mid-America’s largest personal injury law firms. For some time now we have concentrated a lot of our time and resources in the area of dangerous drug litigation. We have partnered with some of the country’s best drug litigation specialists to create a legal team we feel is second to none.      CONTINUE


It’s really terrible to read about a prescription drug being recalled because of dangerous side effects, when you’re one of the people taking it. That’s what happened to me a few years ago. I suffer from a chronic disease and my doctor prescribed a drug to help me manage it better. After being on the drug for a while I began to feel weak and reported it to my doctor. I can’t say enough good things about him, he saved my life. He realized that my problems were being caused not by my disease but by the prescription drug that was supposed to be helping me.   CONTINUE


A lot of people believe that the giant corporations of the world are impossible to beat. Let me assure you this is not true. Everyday, Brown and Crouppen as well as other prominent law firms across America take on these giants and win. The real wonder of the American legal system is that it allows individuals to litigate important matters against giant corporations as equals. If a case has merit our system enables you to win compensation for the harm done. It happens everyday.  CONTINUE


Learn more about other dangerous pharmaceutical drugs and pharmaceutical negligence:

Accutane
Acetaminophen
Arava
Baycol
Celebrex
Crestor
Duragesic Pain Patch
Enbrel
Ephedra
Heart Stent
Meridia
Neurontin
Oxycontin
Paxil
PPA
Prempro / Premarin
Remicade
Rezulin
Serzone
Smith and Nephew Knee Replacement
Stadol
Taxus Coronary Stent
Thimerosal
Vioxx
Zyprexa


Call Brown & Crouppen at 1-800-536-HELP for your free legal consultation or save time with our online Contact Form.

1-800-536-HELP

 


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